BitterDB

hTAS2R46 - Human (Homo sapiens) Taste Receptor Type 2 Member 46 help

hTAS2R46 is a bitter receptor broadly tuned to sesquiterpene lactones, related clerodane diterpenoids,labdane diterpenes and more.

Links and Citations:

P59540
t2r46_human
TAS2R46
ENSG00000226761-TAS2R46
link

Properties help

  • Human
  • chr12:11,213,964-11,214,893 UCSC
  • 113
  • 35,523 (Da)


  • MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQK ISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEV RITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLH LKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEG NMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLIC SLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAI YFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILI WGNKKLKQTFLSVLWHVRYWVKGEKPSSS

Known Ligands help

Please scroll down to see the rest of the ligands.

Download SDF file of selected compounds.

Experimental/ Computational 3D structures help

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

link

link

Protein Diagram help

Receptor snake diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table help

ReceptorLocationBW numberResidueMAFdbSNP
TAS2R46IC3 L228M0.3359rs2708380

Known Mutations Table help

ReceptorLocation BW number Residue References
hTAS2R46TM22.60N65doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM22.61W66doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM22.64T69doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM22.65E70doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46EC12.66L71doi: 10.1016/j.jsamd.2017.03.001
hTAS2R46TM33.26I82doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.29Y85doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.30N86doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.32W88doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.33A89doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.36N92doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R46TM33.37H93doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM33.40N96doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM44.60I147doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46EC24.65N150TOPMed: rs1943619661 TOPMed: rs1943619661
hTAS2R46EC24.76N161TOPMed: rs1476216261 gnomAD: rs1378396828 gnomAD: rs1378396828
hTAS2R46TM55.38S175doi: 10.1021/acs.jctc.5b00472
hTAS2R46TM55.39N176doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R46TM55.43T180doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM55.47N184doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM66.51Y241doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R46TM66.52F242doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675
hTAS2R46TM66.54S244doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM66.55I245doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM66.58S248doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM66.59V249doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46EC36.62E253Ensembl: rs1457753471 gnomAD: rs76147157
hTAS2R46TM77.35E261doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM77.39E265doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM77.42A268doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R46TM77.43F269doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107

Known SNP Table help

ReceptorLocation BW number Residue MAFdbSNP
hTAS2R46IC3 0.00L228M0.3359rs2708380