BitterDB ID=955

Sparteine

BitterDB id=955
Detailed experimental validation described in the associated resource.

References for the compound bitterness

	Resource	Comment
[1]	URL link
[2]	Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[3]	Lossow K, Hübner S, Roudnitzky N, Slack JP, Pollastro F, et al. (2016). Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem 291(29): 15358-77. PubMed 27226572
[4]	Glendinning JI (1994). Is the bitter rejection response always adaptive? Physiol Behav 56(6): 1217-27. PubMed 7878094

Known bitter receptors targets:

Receptor Name	Effective concentration (μM)	EC50 (μM)	References
hTas2r10	300.0		PubMed:27226572
hTas2r46	300.0		PubMed:27226572

Sensory data about the compound bitterness:

Sensory Data Type	Value	Reference
Bitter recognition threshold	0.036 [mM]	Reference

Properties:

Mol. Weight: 234.3900 [g/mol]	AlogP(octanol-water): 2.34510
# Hydrogen Bond Donor: 0	# Hydrogen Bond Acceptor: 2
# Aromatic Rings: 0	# Rings: 4
# Rotatable Bonds: 0
Rat Acute Oral LD50: 959 [mg/kg B.W.]

Identifiers:

CAS Registry Number: 90-39-1

Formula: C15H26N2

SMILES:

Canonical SMILES:

InChI Key: SLRCCWJSBJZJBV-ZQDZILKHSA-N

Links:

[1]

PubChem