Absinthin help

BitterDB id=41 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] URL link
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956
[5] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[6] Cowart BJ, Yokomukai Y, Beauchamp GK (1994). Bitter taste in aging: compound-specific decline in sensitivity. Physiol Behav 56(6): 1237-41. PubMed 7878096
[7] Merck Index Monograph Number: 12

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References Sequence variant
Human  hTas2r10 100.0 PubMed:20022913
Human  hTas2r14 100.0 PubMed:20022913
Human  hTas2r46 1.0 9.9 PubMed:20022913 AAM19318.1
Human  hTas2r47 0.1 0.4 PubMed:20022913 AAM19324.1
Chicken  ggTas2r7 100.0 PubMed:25180257
Mouse  mTas2r110 30.0 PubMed:27226572
Mouse  mTas2r123 100.0 PubMed:27226572
Mouse  mTas2r140 100.0 PubMed:27226572
Fish  ccarpTas2r200-1 100.0 PubMed:34504956
Fish  ccarpTas2r200-2 100.0 PubMed:34504956
Fish  ccarpTas2r203-1 100.0 PubMed:34504956
Bird  tgTas2r1 900.0 PubMed:37860623

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.00013 [mM] Reference

Properties: help

496.6400 [g/mol] 3.80240
2 6
0 7
0

Identifiers: help

1362-42-1
C30H40O6
PZHWYURJZAPXAN-ILOFNVQHSA-N

Links:

[1] 442138