D-salicin, Salicin help

BitterDB id=461 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Rodgers S, Glen RC, Bender A (None). Characterizing bitterness: identification of key structural features and development of a classification model. J Chem Inf Model 46(2): 569-76. PubMed 16562985
[2] Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995
[3] Sakurai T, Misaka T, Ishiguro M, Masuda K, Sugawara T, et al. (2010). Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. J Biol Chem 285(36): 28373-8. PubMed 20605788
[4] Intelmann, D. et al. Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer. Chemosensory Perception 2, 118-132(2009). springerlink imparting a long-lasting bitter taste sensation perceived mainly in the back of the tongue as well as the throat
[5] Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32(3): 397-401. PubMed 12379855
[6] Merck Index Monograph Number: Aq solns are neutral to litmus and have a bitter taste.

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r16 90 1400 PubMed:20022913
Human  hTas2r16 220 PubMed:20605788
Mouse  mTas2r126 10000 PubMed:27226572

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 1.4 [mM] Reference
Bitter recognition threshold 0.2 [mM] Reference
Bitter recognition EC50 1.1 [mM] Reference

Properties: help

286.28 [g/mol] -1.64240
5 7
1 2

Identifiers: help



[1] 439503
[2] ZINC000003847505