Chloramphenicol help

BitterDB id=69 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] URL link
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302
[5] Dey B. et al. Identification of functional bitter taste receptors and their antagonist in chickens, Biochemical and Biophysical Research Communications, 2017, 482(4), 693-699 PubMed 27866985
[6] Fotsing J. R. et al. Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists, Journal of Medicinal Chemistry, 2020, 63(9), 4957-4977 PubMed 32330040
[7] Lu Q. et al. Molecular evolution and deorphanization of bitter taste receptors in a vampire bat, Integrative Zoology, 2021, 16(5), 659-669 PubMed 33289344
[8] Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666
[9] Ziegler F. and Behrens M. Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions in vitro, Proceedings of the Royal Society B: Biological Sciences, 2021, 288(1947) PubMed 33784867
[10] Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956
[11] Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711
[12] Itoigawa A. et al. Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals, Molecular Biology and Evolution, 2022, 39(6) PubMed 35652727
[13] Nolden A. A. Variation in TAS2R receptor genes explains differential bitterness of two common antibiotics, Frontiers in Genetics, 2022, 13 PubMed 35967977
[14] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[15] Chen S. et al. Anti-HIV drugs lopinavir/ritonavir activate bitter taste receptors, Chemical Senses, 2023, 48 PubMed 37625013
[16] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[17] URL link

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References Sequence variant
Human  hTas2r1 100.0 PubMed:20022913
Human  hTas2r1 1000.0 PubMed:34785711
Human  hTas2r8 30.0 555.0 PubMed:20022913
Human  hTas2r8 1000.0 PubMed:34785711
Human  hTas2r8 1000.0 PubMed:37625013
Human  hTas2r8 41.0 PubMed:32330040
Human  hTas2r10 100.0 PubMed:20022913
Human  hTas2r39 1000.0 PubMed:20022913 AAM19321.1
Human  hTas2r41 500.0 PubMed:20022913 AAM19323.1
Human  hTas2r41 1000.0 PubMed:34785711
Human  hTas2r43 100.0 PubMed:20022913
Human  hTas2r46 10.0 PubMed:20022913 AAM19318.1
Chicken  ggTas2r1 100.0 PubMed:25180257
Chicken  ggTas2r2 1000.0 PubMed:25180257
Chicken  ggTas2r7 300.0 PubMed:25180257
Mouse  mTas2r105 30 PubMed:27226572
Mouse  mTas2r119 300 PubMed:27226572
Cat  fcTas2r4 1000.0 PubMed:26488302
Cat  fcTas2r46 1000.0 PubMed:26488302
Vampire Bat  droTas2r1 1000.0 PubMed:33784867
Vampire Bat  droTas2r1 1000.0 PubMed:33289344
Vampire Bat  droTas2r4 1000.0 PubMed:33289344
Vampire Bat  droTas2r7 1000.0 PubMed:33784867
Vampire Bat  droTas2r408 1000.0 PubMed:33289344
Platypus  oaTas2r811 1000.0 PubMed:35652727
Platypus  oaTas2r813a 1000.0 PubMed:35652727
Elephant  laTas2r16c 1000.0 PubMed:35652727
Fish  dreTas2r3a 1000.0 PubMed:33355666
Fish  ccarpTas2r201 1000.0 PubMed:34504956
Fish  ccarpTas2r203-1 1000.0 PubMed:34504956
Frog  lcateTas2r16 1000.0 PubMed:36780530
Bird  tgTas2r5 PubMed:37860623
Turkey  mgTas2r3 PubMed:37860623
Turkey  mgTas2r4 PubMed:37860623

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

323.1300 [g/mol] 0.90900
3 5
1 1
6

Identifiers: help

56-75-7,59112-59-3,85666-84-8
C11H12Cl2N2O5
WIIZWVCIJKGZOK-RKDXNWHRSA-N

Links:

[1] 5959
[2] ZINC000000113382
[3] DB00446