Amarogentin 
BitterDB id=71 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | Glendinning JI (1994). Is the bitter rejection response always adaptive? Physiol Behav 56(6): 1217-27. PubMed 7878094 | |
| [3] | URL link | biterness of 1:58,000,000, most bitter compound known |
| [4] | Merck Index Monograph Number: |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r1 |
30 | PubMed:20022913 | |
|
hTas2r4 |
300 | PubMed:20022913 | |
|
hTas2r39 |
300 | PubMed:20022913 | |
|
hTas2r43 |
30 | PubMed:20022913 | |
|
hTas2r46 |
10 | PubMed:20022913 | |
|
hTas2r47 |
3 | PubMed:20022913 | |
|
hTas2r50 |
100 | PubMed:20022913 | |
ggTas2r7 |
100 | PubMed:25180257 | |
mTas2r105 |
0.3 | 4 | PubMed:27226572 |
|
mTas2r108 |
1000 | PubMed:27226572 | |
|
mTas2r123 |
300 | 160 | PubMed:27226572 |
|
mTas2r144 |
1000 | PubMed:27226572 |
Sensory data about the compound bitterness:
| Sensory Data Type | Value | Reference |
|---|---|---|
| Bitter recognition threshold | 0.004 [mM] | Reference |
| Bitter recognition threshold | 0.000029 [mM] | Reference |
Properties:
| 586.55 [g/mol] | 1.05690 |
| 6 | 13 |
| 2 | 5 |
| 7 |
Identifiers:
| 21018-84-8 |
| C29H30O13 |
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| DBOVHQOUSDWAPQ-WTONXPSSSA-N |
Links:
| [1] | 115149 | ||
| [2] | ZINC000003982136 |
