Amarogentin 
BitterDB id=71 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422 | |
| [3] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [4] | Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956 | |
| [5] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [6] | Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623 | |
| [7] | Behrens M. et al. A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception, Proceedings of the National Academy of Sciences, 2023, 120(48) PubMed 37956436 | |
| [8] | Itoigawa A. et al. Evolutionary origins of bitter taste receptors in jawed vertebrates, Current Biology, 2024, 34(7), 271-272 PubMed 38593768 | |
| [9] | Glendinning JI (1994). Is the bitter rejection response always adaptive? Physiol Behav 56(6): 1217-27. PubMed 7878094 | |
| [10] | URL link | |
| [11] | URL link | biterness of 1:58,000,000, most bitter compound known |
| [12] | Merck Index Monograph Number: 377 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References | Sequence variant |
|---|---|---|---|---|
hTas2r1 |
30 | PubMed:20022913 | ||
|
hTas2r4 |
300 | PubMed:20022913 | ||
|
hTas2r39 |
300.0 | PubMed:20022913 | AAM19321.1 | |
|
hTas2r43 |
30 | PubMed:20022913 | ||
|
hTas2r46 |
10.0 | PubMed:20022913 | AAM19318.1 | |
|
hTas2r47 |
3.0 | PubMed:20022913 | AAM19324.1 | |
|
hTas2r50 |
100.0 | PubMed:20022913 | AAM19326.1 | |
ggTas2r7 |
100.0 | PubMed:25180257 | ||
mTas2r105 |
0.3 | 4 | PubMed:27226572 | |
|
mTas2r108 |
1000 | PubMed:27226572 | ||
|
mTas2r123 |
300 | 160 | PubMed:27226572 | |
|
mTas2r144 |
1000 | PubMed:27226572 | ||
dreTas2r3a |
1000.0 | PubMed:33355666 | ||
|
ccarpTas2r200-1 |
1000.0 | PubMed:34504956 | ||
|
ccarpTas2r201 |
1000.0 | PubMed:34504956 | ||
scTas2r1 |
1000.0 | PubMed:37956436 | ||
|
cplTas2r1 |
1000.0 | PubMed:37956436 | ||
|
cpuTas2r1 |
1000.0 | PubMed:38593768 | ||
|
stTas2r1 |
1000.0 | PubMed:38593768 | ||
tgTas2r1 |
900.0 | PubMed:37860623 | ||
mgTas2r3 |
PubMed:37860623 |
Sensory data about the compound bitterness:
| Sensory Data Type | Value | Reference |
|---|---|---|
| Bitter recognition threshold | 0.004 [mM] | Reference |
| Bitter recognition threshold | 0.000029 [mM] | Reference |
Properties:
| 586.5500 [g/mol] | 1.05690 |
| 6 | 13 |
| 2 | 5 |
| 7 |
Identifiers:
| 21018-84-8 |
| C29H30O13 |
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| DBOVHQOUSDWAPQ-WTONXPSSSA-N |
Links:
| [1] | 115149 | ||
| [2] | ZINC000003982136 |
