Quinine 
BitterDB id=38 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | URL link | |
| [3] | Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422 | |
| [4] | Liu K. et al. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018, 1860, 5, 991-999 PubMed 29355483 | |
| [5] | Freund J. R. et al. Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling, Journal of Biological Chemistry, 2018, 293, 25, 9824-9840 PubMed 29748385 | |
| [6] | Jaggupilli A. et al. Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs), ACS Infectious Diseases, 2018, 4(7), 1146–1156 PubMed 29799189 | |
| [7] | Wang Y. et al. Flavor challenges in extruded plant-based meat alternatives: A review, Comprehensive Reviews in Food Science and Food Safety, 2022, 21(3), 2898-2929 PubMed 35470959 | |
| [8] | Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835 | |
| [9] | Rosa A. et al. Sex Differences in the Bitterness Perception of an Aromatic Myrtle Bitter Liqueur and Bitter Compounds, Nutrients, 2023, 15(9), 2030 PubMed 37432169 | |
| [10] | Nguyen H. et al. Thiazolidinediones are partially effective bitter blockers, bioRxiv, 2023 PubMed 37609224 | |
| [11] | PubChem 8549 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References | Sequence variant |
|---|---|---|---|---|
hTas2r1 |
PubMed:37413835 | |||
|
hTas2r4 |
10.0 | PubMed:20022913 | ||
|
hTas2r4 |
1000.0 | PubMed:29799189 | ||
|
hTas2r7 |
10.0 | PubMed:20022913 | ||
|
hTas2r7 |
983.0 | PubMed:29355483 | ||
|
hTas2r10 |
10.0 | PubMed:20022913 | ||
|
hTas2r14 |
10.0 | PubMed:20022913 | ||
|
hTas2r39 |
10.0 | PubMed:20022913 | AAM19321.1 | |
|
hTas2r40 |
10.0 | PubMed:20022913 | ||
|
hTas2r41 |
PubMed:37413835 | |||
|
hTas2r43 |
10.0 | PubMed:20022913 | ||
|
hTas2r44 |
10.0 | PubMed:20022913 | ||
|
hTas2r46 |
10.0 | PubMed:20022913 | AAM19318.1 | |
ggTas2r1 |
10 | PubMed:25180257 | ||
|
ggTas2r2 |
10 | PubMed:25180257 | ||
|
ggTas2r7 |
10 | PubMed:25180257 | ||
mTas2r105 |
10 | PubMed:27226572 | ||
|
mTas2r115 |
3 | PubMed:27226572 | ||
|
mTas2r126 |
10 | PubMed:27226572 | ||
|
mTas2r137 |
10 | PubMed:27226572 | ||
|
mTas2r138 |
10 | PubMed:27226572 | ||
|
mTas2r140 |
3 | 6 | PubMed:27226572 | |
|
mTas2r144 |
10 | PubMed:27226572 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 324.4200 [g/mol] | 3.17320 |
| 1 | 4 |
| 2 | 5 |
| 4 |
Identifiers:
| 130-95-0,13187-99-0,1407-83-6 |
| C20H24N2O2 |
|
|
|
|
|
|
| LOUPRKONTZGTKE-VOMFEXJBSA-N |
Links:
| [1] | 8549 | |||
| [2] | ZINC000003831404 | ZINC000006484901 | ||
| [3] | DB00468 | |||
| [4] | 2510 |
