Diphenidol help

BitterDB id=62 , Synthetic
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[3] Liu K. et al. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018, 1860, 5, 991-999 PubMed 29355483
[4] Itoigawa A. et al. Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals, Molecular Biology and Evolution, 2022, 39(6) PubMed 35652727
[5] Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835
[6] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References Sequence variant
Human  hTas2r1 100.0 PubMed:20022913
Human  hTas2r4 100.0 PubMed:20022913
Human  hTas2r7 10.0 PubMed:20022913
Human  hTas2r7 675.0 PubMed:29355483
Human  hTas2r10 30.0 PubMed:20022913
Human  hTas2r13 30.0 PubMed:20022913 AAH95518.1
Human  hTas2r14 10.0 PubMed:20022913
Human  hTas2r16 100.0 PubMed:20022913 AAH95524.1
Human  hTas2r38 100.0 PubMed:20022913
Human  hTas2r39 100.0 PubMed:20022913 AAM19321.1
Human  hTas2r40 30 PubMed:20022913
Human  hTas2r41 PubMed:37413835
Human  hTas2r43 30 PubMed:20022913
Human  hTas2r44 3 PubMed:20022913
Human  hTas2r46 30.0 PubMed:20022913 AAM19318.1
Human  hTas2r47 100.0 PubMed:20022913 AAM19324.1
Human  hTas2r49 100 PubMed:20022913
Chicken  ggTas2r1 10.0 PubMed:25180257
Chicken  ggTas2r2 100.0 PubMed:25180257
Chicken  ggTas2r2 65.7 PubMed:25796330
Chicken  ggTas2r7 100.0 PubMed:25180257
Mouse  mTas2r105 10 PubMed:27226572
Mouse  mTas2r108 100 PubMed:27226572
Mouse  mTas2r110 100 PubMed:27226572
Mouse  mTas2r123 10 PubMed:27226572
Mouse  mTas2r137 100 PubMed:27226572
Mouse  mTas2r144 100 PubMed:27226572
Cat  fcTas2r2 PubMed:26488302
Cat  fcTas2r38 PubMed:26488302
Cat  fcTas2r46 PubMed:26488302
Cat  fcTas2r67 PubMed:26488302
Platypus  oaTas2r812 100.0 PubMed:35652727
Bird  tgTas2r5 PubMed:37860623
Bird  tgTas2r6 PubMed:37860623
Turkey  mgTas2r3 PubMed:37860623
Turkey  mgTas2r4 PubMed:37860623

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

309.4500 [g/mol] 4.18860
1 2
2 3
6

Identifiers: help

150969-57-6,19-11-4,5336-12-9,722544-51-6,972-02-1
C21H27NO
OGAKLTJNUQRZJU-UHFFFAOYSA-N

Links:

[1] 3055
[2] ZINC000000968266
[3] DB01231
[4] 7163