BitterDB ID=2142

11(S),13-Dihydrolactucopicrin, 11,13-dihydrolactucopicrin, 11b,13-dihydrolactucopicrin

BitterDB id=2142
Detailed experimental validation described in the associated resource.

References for the compound bitterness

	Resource	Comment
[1]	URL link
[2]	Yanagisawa T. and Misaka T. Characterization of the Human Bitter Taste Receptor Response to Sesquiterpene Lactones from Edible Asteraceae Species and Suppression of Bitterness through pH Control, ACS Omega, 2021, 6(6), 4401â€“4407 PubMed 33644553
[3]	Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875

Known bitter receptors targets:

Receptor Name	Effective concentration (μM)	EC50 (μM)	References
hTas2r46	100.0	2.0	PubMed:33644553

Sensory data about the compound bitterness:

Sensory Data Type	Value	Reference
Bitter recognition threshold	0.00048 [mM]	Reference

Properties:

Mol. Weight: 412.4325 [g/mol]	AlogP(octanol-water): 2.01630
# Hydrogen Bond Donor: 2	# Hydrogen Bond Acceptor: 7
# Aromatic Rings: 1	# Rings: 4
# Rotatable Bonds: 5

Identifiers:

Formula: C23H24O7

IUPAC Systematic Name:

SMILES:

Canonical SMILES:

InChI Key: ICJJPTZLMALYBH-ZUQDHHQASA-N

Links:

[1]	PubChem	14565842
[2]	ZINC	ZINC000238742945