Methoxsalen, Xanthotoxin 
BitterDB id=315 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | URL link | |
| [2] | URL link | |
| [3] | Mancuso G. et al. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception, Molecules, 2015, 20(10), 18907-18922 PubMed 26501253 | |
| [4] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [5] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [6] | Mancuso G, Borgonovo G, Scaglioni L, Bassoli A (2015). Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules 20(10): 18907-22. PubMed 26501253 | |
| [7] | Merck Index Monograph Number: 5988 | bitter taste followed by tingling sensation |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r4 |
1000.0 | PubMed:27226572 | |
|
hTas2r4 |
1000.0 | PubMed:26501253 | |
|
hTas2r10 |
100.0 | 20.6 | PubMed:27226572 |
|
hTas2r10 |
100.0 | 20.6 | PubMed:26501253 |
|
hTas2r14 |
100.0 | 10.8 | PubMed:27226572 |
|
hTas2r14 |
100.0 | 10.8 | PubMed:26501253 |
|
hTas2r46 |
100.0 | PubMed:27226572 | |
|
hTas2r46 |
100.0 | PubMed:26501253 | |
|
hTas2r49 |
12.0 | PubMed:27226572 | |
|
hTas2r49 |
12.0 | PubMed:26501253 | |
mTas2r105 |
10 | PubMed:27226572 | |
|
mTas2r119 |
100 | PubMed:27226572 | |
|
mTas2r120 |
30 | PubMed:27226572 | |
|
mTas2r121 |
100 | PubMed:27226572 | |
|
mTas2r135 |
100 | PubMed:27226572 | |
dreTas2r3a |
100.0 | PubMed:33355666 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 216.1900 [g/mol] | 2.54780 |
| 0 | 4 |
| 3 | 3 |
| 1 | |
| 790 [mg/kg B.W.] |
Identifiers:
| 298-81-7,56-93-9 |
| C12H8O4 |
|
|
|
|
|
|
| QXKHYNVANLEOEG-UHFFFAOYSA-N |
Links:
| [1] | 4114 | ||
| [2] | ZINC000002548959 | ||
| [3] | DB00553 |
