Tangeretin help

BitterDB id=810 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Drewnowski A, Gomez-Carneros C (2000). Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72(6): 1424-35. PubMed 11101467 '
[2] URL link
[3] Behrens M. et al. Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors, Chem Biol Drug Des, 2018, 91, 422– 433 PubMed 28834122
[4] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[5] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[6] Chen L. et al. 3D-QSAR studies on the structure–bitterness analysis of citrus flavonoids, Food & Function, 2023, 14(10), 4921-4930 PubMed 37158134

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 63 PubMed:26934534
Human  hTas2r14 0.33 PubMed:27379685
Human  hTas2r14 50.0 PubMed:28834122
Human  hTas2r14 0.33 PubMed:36871162
Human  hTas2r46 4.53 PubMed:27379685
Human  hTas2r46 20.0 PubMed:28834122
Human  hTas2r46 4.53 PubMed:36871162

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.08862 [mM] Reference
Bitter recognition threshold 0.1 [mM] Reference

Properties: help

372.3700 [g/mol] 3.50300
0 7
3 3
6

Identifiers: help

481-53-8,50816-93-8
C20H20O7
ULSUXBXHSYSGDT-UHFFFAOYSA-N

Links:

[1] 68077
[2] ZINC000001531699