Quassin help

BitterDB id=55 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Rodgers S, Glen RC, Bender A (None). Characterizing bitterness: identification of key structural features and development of a classification model. J Chem Inf Model 46(2): 569-76. PubMed 16562985
[2] Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995
[3] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[4] URL link
[5] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[6] Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666
[7] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[8] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[9] Merck Index Monograph Number: 8026 Very bitter rectangular plates from dilute methanol

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References Sequence variant
Human  hTas2r4 300.0 PubMed:20022913
Human  hTas2r10 300.0 PubMed:20022913
Human  hTas2r14 300.0 PubMed:20022913
Human  hTas2r46 300.0 PubMed:20022913 AAM19318.1
Human  hTas2r47 300.0 PubMed:20022913 AAM19324.1
Chicken  ggTas2r7 300.0 PubMed:25180257
Mouse  mTas2r105 300.0 PubMed:27226572
Fish  dreTas2r4 300.0 PubMed:33355666

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

388.4600 [g/mol] 2.81900
0 6
0 4
2

Identifiers: help

76-78-8
C22H28O6
IOSXSVZRTUWBHC-LBTVDEKVSA-N

Links:

[1] 65571
[2] ZINC000003978633