Parthenolide 
BitterDB id=54 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | URL link | |
| [3] | Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422 | |
| [4] | Yanagisawa T. and Misaka T. Characterization of the Human Bitter Taste Receptor Response to Sesquiterpene Lactones from Edible Asteraceae Species and Suppression of Bitterness through pH Control, ACS Omega, 2021, 6(6), 4401–4407 PubMed 33644553 | |
| [5] | Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835 | |
| [6] | Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References | Sequence variant |
|---|---|---|---|---|
hTas2r1 |
100.0 | PubMed:20022913 | ||
|
hTas2r4 |
30.0 | PubMed:20022913 | ||
|
hTas2r8 |
100.0 | PubMed:20022913 | ||
|
hTas2r10 |
30.0 | 69.1 | PubMed:20022913 | |
|
hTas2r14 |
3.0 | 10.0 | PubMed:20022913 | |
|
hTas2r41 |
PubMed:37413835 | |||
|
hTas2r44 |
100.0 | PubMed:20022913 | ||
|
hTas2r46 |
1.0 | PubMed:20022913 | AAM19318.1 | |
|
hTas2r46 |
300.0 | PubMed:33644553 | ||
ggTas2r2 |
10.0 | PubMed:25180257 | ||
|
ggTas2r7 |
100.0 | PubMed:25180257 | ||
mTas2r105 |
100 | PubMed:27226572 | ||
mgTas2r3 |
PubMed:37860623 | |||
|
mgTas2r4 |
PubMed:37860623 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 248.3200 [g/mol] | 2.76200 |
| 0 | 3 |
| 0 | 3 |
| 0 |
Identifiers:
| 20554-84-1 |
| C15H20O3 |
|
|
|
|
| KTEXNACQROZXEV-SLXBATTESA-N |
