Taurocholic acid 
BitterDB id=977
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | URL link | |
| [2] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [3] | Ziegler F. et al. Physiological activation of human and mouse bitter taste receptors by bile acids, Communications Biology, 2023, 6, 612 PubMed 37286811 | |
| [4] | Lossow K, Hübner S, Roudnitzky N, Slack JP, Pollastro F, et al. (2016). Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem 291(29): 15358-77. PubMed 27226572 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r1 |
100.0 | PubMed:37286811 | |
|
hTas2r4 |
300.0 | PubMed:27226572 | |
|
hTas2r4 |
100.0 | PubMed:37286811 | |
|
hTas2r14 |
300.0 | PubMed:37286811 | |
|
hTas2r39 |
300.0 | PubMed:37286811 | |
|
hTas2r46 |
1000.0 | PubMed:37286811 | |
mTas2r108 |
100.0 | PubMed:37286811 | |
|
mTas2r117 |
140.0 | PubMed:27226572 | |
|
mTas2r117 |
30.0 | 37.4 | PubMed:37286811 |
|
mTas2r123 |
80.0 | PubMed:27226572 | |
|
mTas2r123 |
100.0 | PubMed:37286811 | |
|
mTas2r144 |
150.0 | PubMed:27226572 | |
|
mTas2r144 |
100.0 | PubMed:37286811 | |
lchTas2r2 |
300.0 | PubMed:33355666 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 515.7100 [g/mol] | 2.36810 |
| 5 | 6 |
| 0 | 4 |
| 7 |
Identifiers:
| 81-24-3,83830-80-2 |
| C26H45NO7S |
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| WBWWGRHZICKQGZ-HZAMXZRMSA-N |
Links:
| [1] | 6675 |
