Santonin (-)-Form 
BitterDB id=465
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | URL link | |
| [2] | URL link | |
| [3] | URL link | |
| [4] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [5] | Yanagisawa T. and Misaka T. Characterization of the Human Bitter Taste Receptor Response to Sesquiterpene Lactones from Edible Asteraceae Species and Suppression of Bitterness through pH Control, ACS Omega, 2021, 6(6), 4401–4407 PubMed 33644553 | |
| [6] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [7] | Merck Index Monograph Number: 8361 | Almost tasteless with bitter aftertaste |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r10 |
100.0 | PubMed:27226572 | |
|
hTas2r10 |
100.0 | PubMed:23283334 | |
|
hTas2r10 |
100.0 | PubMed:30009876 | |
|
hTas2r14 |
100.0 | 9.03 | PubMed:27226572 |
|
hTas2r14 |
100.0 | 9.03 | PubMed:23283334 |
|
hTas2r14 |
100.0 | 9.03 | PubMed:30009876 |
|
hTas2r46 |
100.0 | PubMed:27226572 | |
|
hTas2r46 |
300.0 | PubMed:33644553 | |
|
hTas2r46 |
100.0 | PubMed:23283334 | |
|
hTas2r46 |
100.0 | PubMed:30009876 | |
mTas2r105 |
300 | PubMed:27226572 | |
|
mTas2r114 |
1000 | PubMed:27226572 | |
dreTas2r3a |
100.0 | PubMed:33355666 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 246.3100 [g/mol] | 2.41960 |
| 0 | 3 |
| 0 | 3 |
| 0 |
Identifiers:
| 481-06-1 |
| C15H18O3 |
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| XJHDMGJURBVLLE-BOCCBSBMSA-N |
