Nomilin help

BitterDB id=348 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] URL link Bitter
[2] Drewnowski A, Gomez-Carneros C (2000). Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72(6): 1424-35. PubMed 11101467
[3] URL link
[4] Behrens M. et al. Bitter substances from plants used in traditional Chinese medicine exert biased activation of human bitter taste receptors, Chem Biol Drug Des, 2018, 91, 422– 433 PubMed 28834122
[5] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[6] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[7] Merck Index Monograph Number: 6674

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r4 50.0 PubMed:28834122
Human  hTas2r14 20.0 PubMed:28834122
Human  hTas2r46 20.0 PubMed:28834122

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.00408 [mM] Reference

Properties: help

514.5700 [g/mol] 3.69020
0 9
1 6
2

Identifiers: help

1063-77-0
C28H34O9
KPDOJFFZKAUIOE-WNGDLQANSA-N

Links:

[1] 72320
[2] ZINC000004097787