Sucralose 
BitterDB id=956
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Gibbs M. et al. Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion, PLOS ONE, 2022, 17(11) PubMed 36449493 | |
| [2] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [3] | Lossow K, Hübner S, Roudnitzky N, Slack JP, Pollastro F, et al. (2016). Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem 291(29): 15358-77. PubMed 27226572 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r1 |
PubMed:27226572 | ||
|
hTas2r4 |
PubMed:27226572 | ||
|
hTas2r5 |
PubMed:27226572 | ||
|
hTas2r7 |
PubMed:27226572 | ||
|
hTas2r8 |
PubMed:27226572 | ||
|
hTas2r10 |
PubMed:27226572 | ||
|
hTas2r39 |
PubMed:27226572 | ||
|
hTas2r41 |
PubMed:27226572 | ||
|
hTas2r46 |
PubMed:27226572 | ||
mTas2r105 |
130 | PubMed:27226572 | |
|
mTas2r109 |
60 | PubMed:27226572 | |
|
mTas2r115 |
560 | PubMed:27226572 | |
|
mTas2r117 |
220 | 4900 | PubMed:27226572 |
|
mTas2r123 |
70 | PubMed:27226572 | |
|
mTas2r139 |
130 | PubMed:27226572 | |
|
mTas2r144 |
100 | PubMed:27226572 | |
cfTas2r4 |
1230.0 | PubMed:36449493 | |
|
cfTas2r5 |
33330.0 | 42910.0 | PubMed:36449493 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 397.6400 [g/mol] | -1.65610 |
| 5 | 8 |
| 0 | 2 |
| 5 |
Identifiers:
| 56038-13-2 |
| C12H19Cl3O8 |
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| BAQAVOSOZGMPRM-QBMZZYIRSA-N |
Links:
| [1] | 71485 |
