BitterDB

Please scroll down to see the rest of the ligands.

Download SDF file of selected compounds.

	Quinine
	Azathioprine
	Chlorpheniramine
	Diphenidol
	Thiamine
	Chloramphenicol
	Amarogentin
	Chloroquine
	Colchicine
	Denatonium benzoate
	Acetaminophen
	Quercetin
	Naringenin
	L-Histidine
	D-phenylalanine,D-Phe,L-phenylalanine,L-Phe
	Genistein
	Daidzein
	(+/-) Equol
	Epigallocatechin gallate, egcg,Epigallocatechin gallate,EGCG
	Catechin
	EC,(+)-Catechin,Epicatechin,(-)-Epicatechin
	(-)-Epigallocatechin (EGC),Epigallocatechin,Gallocatechol
	(-)-Epicatechin gallate,Ecg,Epicatechin gallate
	Genistin
	Coumestrol
	L-trp,L-tryptophan
	LW,Leu-trp
	Trp-Trp,WW
	Pro-arg,Prolylarginine
	Apigenin
	Chrysin
	5,2'-dihydroxyflavone
	5,4'-dihydroxyflavone
	6,4'-dihydroxyflavone
	7,4-'dihydroxyflavone
	5,7'-dimethoxyflavonee
	Flavone
	Genkwanin
	5-hydroxyflavone
	4'-hydroxyflavone
	4'-hydroxy-7-methoxyflavone
	Luteolin
	6-methoxyluteolinb
	Scutellarein
	Tricetin
	5,7,2'-trihydroxyflavone
	7,3',4'-trihydroxyflavone
	Datiscetinb
	Fisetin
	Gossypetind
	Herbacetin
	Isorhamnetin
	Kaempferol,Kaempherol
	Morin
	Myricetind
	Quercetagetin
	3,6,3,4-tetrahydroxyflavone
	3,7,4-trihydroxyflavone
	Eriodictyolb,Eriodictyol
	Hesperetin,Hesperitin
	Homoeriodictyolc,Homoeriodictyol
	Liquiritigenin
	Pinocembrin
	Fustin
	Silibinind,Silibinin
	(+)-taxifolin,taxifoline,taxifolin
	Butein
	3,2-dihydroxychalcone,3,2'-Dihydroxychalcone
	Eriodictyolchalconec,Eriodictyol chalcone
	Isoliquiritigenin
	2,2,4-trihydroxychalcone
	4,2,5-trihydroxychalconee
	Phloretinb
	Cyanidin chloridec
	Pelargoninidin chloride
	Acetylgenistin
	Biochanin Ag
	Formomonetin
	Glyciteing
	Glyciting,Glycitin
	7-hydroxyisoflavoneg
	6,7,4-trihydroxyisoflavone
	7,8,4-trihydroxyisoflavone
	7,3,4-trihydroxyisoflavone
	Resveratrol
	Sulfuretinc,Sulfuretin
	Xanthonee
	Denatonium saccharide
	Sucralose
	Pyrocatechin
	Taurocholic acid
	2-(1H-indol-3-yl)ethanol
	PGG,Pentagalloylglucose (PGG)
	Trp-Trp-Trp
	LVYPFPGPIHN,Leu-Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn
	YPFPGPIHNS,Tyr-Pro-Phe-Pro-Gly-Pro-Ile-His-Asn-Ser
	Iso-Phe,IF,Ile-Phe,Isoleucine-Phenylalanine
	Ranitidine
	Theaflavin-3'-O-gallate
	Theaflavin
	pelargoninidin chloride,Pelargonidin chloride
	Malonylgenistin
	Vitamin B1
	Vanillin
	Procyanidin B2,Procyanidin B2g (3-O-gallate)
	Acetylgenistin
	d-Phenylalanine
	L-Trp,L-Tryptophan,D-Trp,D-Tryptophan
	Cyanidin chloride
	Cyanidin chloride
	Pelargonidin chloride
	Cholate,Cholic acid
	Glycocholate
	Tenofovir alafenamide
	Tenofovir alafenamide fumarate (TAF)
	Phe-Phe-Pro-Arg,FFPR
	Nirmatrelvir
	Amarogentin
	Procyanidin B1,Procyanidin B2g,Procyanidin B4
	L-Alanine
	2,2',4'-trihydroxychalcone
	3,2-dihydroxychalcone

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

RCSB PDB: link

AlphaFold: link

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

No SNPs were reported yet.

Receptor	Location	BW number	Residue	References
hTAS2R39	TM3	3.32	F117	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM3	3.33	I118	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM3	3.36	N121	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM3	3.37	F122	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM3	3.40	L125	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM4	4.56	F170	doi: 10.1371/journal.pone.0118200
hTAS2R39	TM5	5.40	A210	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM5	5.41	F211	doi: 10.1371/journal.pone.0118200
hTAS2R39	TM5	5.44	N214	doi: 10.1371/journal.pone.0118200
hTAS2R39	TM5	5.45	L215	doi: 10.1371/journal.pone.0118200
hTAS2R39	TM6	6.48	I272	doi: 10.1371/journal.pone.0118200
hTAS2R39	TM6	6.51	A275	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM6	6.52	V276	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM6	6.55	F279	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM6	6.56	I280	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM7	7.35	N293	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM7	7.39	Q297	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0118200
hTAS2R39	TM7	7.45	Y303	doi: 10.1371/journal.pone.0118200

Receptor	Location	BW number	Residue	MAF	dbSNP
hTAS2R39		0.00	K197E	0.0000	rs34169190
hTAS2R39		0.00	S193F	0.0000	rs35474877

UniProt	P59534
GPCRDB	t2r39_human
GeneCards	TAS2R39
The Human Protein Atlas	ENSG00000236398-TAS2R39
IUPHAR/BPS	link

BitterDB

hTAS2R39 - Human (Homo sapiens) Taste Receptor Type 2 Member 39

Links and Citations:

Properties

Known Ligands

Experimental/ Computational 3D structures

Protein Diagram

SNPs Table

Known Mutations Table

Known SNP Table