Myricetind help

BitterDB id=888
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Roland WS, van Buren L, Gruppen H, Driesse M, Gouka RJ, et al. (2013). Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39. J Agric Food Chem 61(44): 10454-66. PubMed 24117141
[2] URL link
[3] Roland W. S. U. et al. Bitter Taste Receptor Activation by Flavonoids and Isoflavonoids: Modeled Structural Requirements for Activation of hTAS2R14 and hTAS2R39, J. Agric. Food Chem., 2013, 61, 44, 10454–10466 PubMed 24117141
[4] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[5] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[6] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 250.0 PubMed:24117141
Human  hTas2r14 250.0 PubMed:36871162
Human  hTas2r14 250.0 PubMed:37110532
Human  hTas2r39 1.0 PubMed:24117141
Human  hTas2r39 1.0 PubMed:36871162
Human  hTas2r39 0.5 PubMed:37110532

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.0314200 [mM] Reference

Properties: help

318.2400 [g/mol] 1.69360
6 8
3 3
1

Identifiers: help

529-44-2
C15H10O8
IKMDFBPHZNJCSN-UHFFFAOYSA-N

Links:

[1] 5281672
[2] ZINC000003874317
[3] DB02375