(-)-Epigallocatechin (EGC), Epigallocatechin, Gallocatechol help

BitterDB id=814 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Drewnowski A, Gomez-Carneros C (2000). Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72(6): 1424-35. PubMed 11101467 '
[2] URL link
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Roland W. S. U. et al. Bitter Taste Receptor Activation by Flavonoids and Isoflavonoids: Modeled Structural Requirements for Activation of hTAS2R14 and hTAS2R39, J. Agric. Food Chem., 2013, 61, 44, 10454–10466 PubMed 24117141
[5] Xu Y.-Q. et al. Quantitative analyses of the bitterness and astringency of catechins from green tea, Food Chemistry, 2018, 258, 16-24 PubMed 29655718
[6] Deng S. et al. Bitter and astringent substances in green tea: composition, human perception mechanisms, evaluation methods and factors influencing their formation, Food Research International, 2022, 157, 111262 PubMed 35761574
[7] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[8] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 PubMed:35761574
Human  hTas2r39 395.5 PubMed:21272567
Human  hTas2r39 500.0 PubMed:24117141
Human  hTas2r39 500.0 PubMed:36871162
Human  hTas2r39 500.0 395.5 PubMed:37110532

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.52 [mM] Reference

Properties: help

306.2700 [g/mol] 1.25170
6 7
2 3
1

Identifiers: help

1617-55-6,5154-02-9,970-74-1
C15H14O7
XMOCLSLCDHWDHP-IUODEOHRSA-N

Links:

[1] 72277
[2] ZINC000003870336
[3] DB03823