Apigenin help

BitterDB id=859
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Roland WS, van Buren L, Gruppen H, Driesse M, Gouka RJ, et al. (2013). Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39. J Agric Food Chem 61(44): 10454-66. PubMed 24117141
[2] URL link
[3] Roland W. S. U. et al. Bitter Taste Receptor Activation by Flavonoids and Isoflavonoids: Modeled Structural Requirements for Activation of hTAS2R14 and hTAS2R39, J. Agric. Food Chem., 2013, 61, 44, 10454–10466 PubMed 24117141
[4] Margulis E. et al. BitterMatch: recommendation systems for matching molecules with bitter taste receptors, J Cheminform, 2022, 14, 45 PubMed 35799226
[5] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 8.0 PubMed:23214402
Human  hTas2r14 8.0 PubMed:24117141
Human  hTas2r14 3.0 PubMed:35799226
Human  hTas2r14 8.0 PubMed:36871162
Human  hTas2r39 1.0 PubMed:23214402
Human  hTas2r39 1.0 PubMed:24117141
Human  hTas2r39 1.0 PubMed:36871162
Human  hTas2r43 30.0 PubMed:35799226

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

270.2400 [g/mol] 2.57680
3 5
3 3
1

Identifiers: help

461015-54-3,520-36-5
C15H10O5
KZNIFHPLKGYRTM-UHFFFAOYSA-N

Links:

[1] 5280443
[2] ZINC000003871576
[3] DB07352
[4] 4136