L-Histidine help

BitterDB id=705
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] George A . Burdock (2005) Fenaroli's Handbook of Flavor Ingredients, Fifth Edition, CRC Press slightly bitter taste
[2] Rodgers S, Glen RC, Bender A (None). Characterizing bitterness: identification of key structural features and development of a classification model. J Chem Inf Model 46(2): 569-76. PubMed 16562985
[3] link bitter
[4] URL link
[5] Delompre T. et al. Taste Perception of Nutrients Found in Nutritional Supplements: A Review, Nutrients, 2019, 11(9), 2050 PubMed 31480669
[6] Gunther-Jordanland K. Quantitation and Taste Contribution of Sensory Active Molecules in Oat (Avena sativa L.), Journal of Agricultural and Food Chemistry, 2020, 68 (37), 10097-10108 PubMed 32786831
[7] Junger M. Sensoproteomic Discovery of Taste-Modulating Peptides and Taste Re-engineering of Soy Sauce, Journal of Agricultural and Food Chemistry, 2022, 70 (21), 6503-6518 PubMed 35593506
[8] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 650.0 1249.0 PubMed:24472524
Human  hTas2r8 430.0 534.0 PubMed:24472524
Human  hTas2r39 430.0 PubMed:24472524

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 45.0 [mM] Reference
Bitter recognition threshold 48.0 [mM] Reference
Bitter recognition threshold 48.0 [mM] Reference

Properties: help

155.1600 [g/mol] -0.63590
3 3
1 1
3

Identifiers: help

71-00-1
C6H9N3O2
HNDVDQJCIGZPNO-YFKPBYRVSA-N

Links:

[1] 6274
[2] ZINC000006661227 ZINC000006661404
[3] DB00117