BitterDB

hTAS2R44 - Human (Homo sapiens) Taste Receptor Type 2 Member 44

Alternative Names: Taste receptor type 2 member 31 T2R31, Taste receptor type 2 member 53 T2R53

Links and Citations:

UniProt	P59538
GPCRDB	t2r31_human
GeneCards	TAS2R31
The Human Protein Atlas	ENSG00000256436-TAS2R31
IUPHAR/BPS	link

Properties

Organism: Human
Location: chr12:11,182,986-11,184,006 UCSC
Number of known ligands: 14
MW: 35,296 (Da)
Sequence:

MTTFIPIIFSSVVVVLFVIGNFANGFIALVNSIERVKRQK ISFADQILTALAVSRVGLLWVLLLNWYSTVFNPAFYSVEV RTTAYNVWAVTGHFSNWLATSLSIFYLLKIANFSNLIFLH LKRRVKSVILVMLLGPLLFLACQLFVINMKEIVRTKEYEG NMTWKIKLRSAVYLSDATVTTLGNLVPFTLTLLCFLLLIC SLCKHLKKMQLHGKGSQDPSTKVHIKALQTVIFFLLLCAV YFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILI WGNKKLKQTFLSVLRQVRYWVKGEKPSSP

Known Ligands

Experimental/ Computational 3D structures

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

RCSB PDB: link

AlphaFold: link

Protein Diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R44		1.64	R35W	0.3355	rs10845295
TAS2R44	EC2		L162M	0.2993	rs10743938
TAS2R44	IC3		Q217E	0.1226	rs10845294
TAS2R44		6.37	A227V	0.3498	rs10845293
TAS2R44		6.5	V240I	0.3353	rs10772423
TAS2R44		7.5	P276R	0.1226	rs12318612

Known Mutations Table

Receptor	Location	BW number	Residue	References
hTAS2R44	TM3	3.26	T82	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R44	TM3	3.30	N86	doi: 10.1093/chemse/bjh064 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R44	TM3	3.31	V87	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107
hTAS2R44	TM3	3.32	W88	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R44	TM3	3.35	T91	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107
hTAS2R44	TM3	3.36	G92	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R44	TM5	5.39	D176	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107
hTAS2R44	TM7	7.39	K265	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R44	TM7	7.42	R268	doi: 10.1093/chemse/bjh064 doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005

Known SNP Table

Receptor	Location	BW number	Residue	MAF	dbSNP
hTAS2R44		6.37	A227V	0.3498	rs10845293
hTAS2R44	EC2	0.00	L162M	0.2993	rs10743938
hTAS2R44		7.50	P276R	0.1226	rs12318612
hTAS2R44	IC3	0.00	Q217E	0.1226	rs10845294
hTAS2R44		1.64	R35W	0.3355	rs10845295
hTAS2R44		6.50	V240I	0.3353	rs10772423

	Quinine
	Aristolochic acid
	Parthenolide
	Diphenidol
	Famotidine
	Acesulfame K
	Aloin
	Saccharin
	Andrographolide
	Quercetin
	6-Nitrosaccharin
	Fisetin
	Pantothenic acid
	Aloin