BitterDB

Please scroll down to see the rest of the ligands.

Download SDF file of selected compounds.

	Chlorpheniramine
	Diphenidol
	Diphenylthiourea,Sulfocarbanilide,sym-Diphenylthiourea,Thiocarbanilide
	Yohimbine
	Sodium thiocyanate
	Sodium cyclamate
	Sinigrin
	Acetylthiourea
	allyl isothiocyanate
	Caprolactam
	Dimethylthioformamide
	Ethylpyrazine
	N-ethylthiourea
	Ethylene Thiourea,N,N-ethylene thiourea
	Limonin
	Methimazole
	N-methylthiourea
	Phenethyl isothiocyanate
	Phenylthiocarbamide (PTC)
	Propylthiouracil
	Dimethyl Sulfoxide
	6-Methyl-2-thiouracil,Methylthiouracil
	Berberine
	6-Nitrosaccharin
	N-butyryl-L-homoserine (C4-HSL),homoserine lactone, N-butyryl-L-
	2-Heptyl-3-hydroxy-quinolone
	5-propyl-2-thiouracil
	N-3-Oxo-Dodecanoyl-L-Homoserine Lactone,3-oxo-C12-AHL
	Soyasaponin I,Soyasaponin Î²b
	Vitamin A
	Acetone
	Methyl Ethyl Ketone
	2-Pentanone
	Isobutyraldehyde
	gamma-Butyrolactone
	Dimethyl disulfide
	Methanethiol

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

RCSB PDB: link

AlphaFold: link

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R38	IC1		A49P	0.4952	rs713598
TAS2R38		6.54	V262A	0.4255	rs1726866
TAS2R38		7.52	I296V	0.4794	rs10246939

Receptor	Location	BW number	Residue	References
hTAS2R38	TM3	3.32	W99	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM3	3.33	M100	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM3	3.36	N103	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	EC2	5.24	N179	doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	EC2	5.26	R181	doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	EC2	5.28	N183	doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM5	5.42	F197	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM5	5.46	W201	doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM6	6.47	F255	Cosmic: COSV71885308
hTAS2R38	TM6	6.51	S259	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM6	6.52	S260	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675
hTAS2R38	TM6	6.56	F264	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675 doi: 10.1016/j.jsamd.2017.03.001
hTAS2R38	TM7	7.52	I296	doi: 10.1371/journal.pone.0012394

Receptor	Location	BW number	Residue	MAF	dbSNP
hTAS2R38	IC1	0.00	A49P	0.4952	rs713598
hTAS2R38		7.52	I296V	0.4794	rs10246939
hTAS2R38		6.54	V262A	0.4255	rs1726866

UniProt	P59533
GPCRDB	t2r38_human
GeneCards	TAS2R38
The Human Protein Atlas	ENSG00000257138-TAS2R38
IUPHAR/BPS	link

BitterDB

hTAS2R38 - Human (Homo sapiens) Taste Receptor Type 2 Member 38

Links and Citations:

Properties

Known Ligands

Experimental/ Computational 3D structures

Protein Diagram

SNPs Table

Known Mutations Table

Known SNP Table