Limonin help

BitterDB id=114 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] Drewnowski A, Gomez-Carneros C (2000). Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 72(6): 1424-35. PubMed 11101467
[3] URL link
[4] Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302
[5] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[6] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[7] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[8] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[9] Guinard JX, Hong DY, Zoumas-Morse C, Budwig C, Russell GF (1994). Chemoreception and perception of the bitterness of isohumulones. Physiol Behav 56(6): 1257-63. PubMed 7878099
[10] URL link bitter tasting
[11] Merck Index Monograph Number: 5494

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r38 100.0 PubMed:20022913
Cat  fcTas2r2 300.0 PubMed:26488302
Cat  fcTas2r46 300.0 PubMed:26488302
Bird  tgTas2r1 900.0 PubMed:37860623
Turkey  mgTas2r3 PubMed:37860623

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.0021200 [mM] Reference
Bitter recognition threshold 0.075 [mM] Reference

Properties: help

470.5200 [g/mol] 3.13740
0 8
1 7
1

Identifiers: help

1180-71-8
C26H30O8
KBDSLGBFQAGHBE-MSGMIQHVSA-N

Links:

[1] 179651
[2] ZINC000004096134