Phenylthiocarbamide (PTC) 
BitterDB id=119 , Synthetic
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995 | |
| [2] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [3] | Wooding S.et al. Independent evolution of bitter-taste sensitivity in humans and chimpanzees, Nature, 2006, 440, 930–934 PubMed 16612383 | |
| [4] | Sandau M. M. et al. A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs, BMC Neuroscience, 2015, 16(33) PubMed 26037485 | |
| [5] | Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302 | |
| [6] | Tsutsui K. et al. Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys, BMC Ecology and Evolution, 2016, 16(208) PubMed 27733116 | |
| [7] | Sari P. L. H. P. et al. Functional characterization of the TAS2R38 bitter taste receptor for phenylthiocarbamide in colobine monkeys, Biology Letters, 2017, 13(1) PubMed 28123110 | |
| [8] | Widayati K. A. et al. Functional divergence of the bitter receptor TAS2R38 in Sulawesi macaques, Ecology and Evolution, 2019, 9(18), 10387-10403 PubMed 31624557 | |
| [9] | Purba L. H. P. S. et al. Evolution of the bitter taste receptor TAS2R38 in colobines, Primates, 2020, 61, 485–494 PubMed 32006126 | |
| [10] | Lu Q. et al. Molecular evolution and deorphanization of bitter taste receptors in a vampire bat, Integrative Zoology, 2021, 16(5), 659-669 PubMed 33289344 | |
| [11] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [12] | Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532 | |
| [13] | Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623 | |
| [14] | Merck Index Monograph Number: 7315 | depending upon heredity of taster |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r38 |
0.04 | PubMed:20022913 | |
|
hTas2r38 |
100.0 | 2.3 | PubMed:26037485 |
|
hTas2r38 |
0.02 | 1.1 | PubMed:37110532 |
fcTas2r38 |
100.0 | 76.0 | PubMed:26488302 |
|
fcTas2r38 |
47 | PubMed:29445727 | |
|
fcTas2r38 |
100.0 | 47.0 | PubMed:26037485 |
cfTas2r38 |
47.0 | PubMed:26037485 | |
droTas2r408 |
100.0 | PubMed:33289344 | |
tgTas2r5 |
PubMed:37860623 | ||
ptTas2r38 |
2.6 | PubMed:16612383 | |
|
ptTas2r38 |
2.6 | PubMed:27733116 | |
|
mfTas2r38 |
1.56 | PubMed:32006126 | |
|
cgTas2r38 |
5.99 | PubMed:32006126 | |
|
cangTas2r38-A |
13.34 | PubMed:32006126 | |
|
mhTas2r38 |
PubMed:28123110 | ||
|
mtTas2r38 |
PubMed:31624557 |
Sensory data about the compound bitterness:
| Sensory Data Type | Value | Reference |
|---|---|---|
| Bitter recognition threshold | 0.00328 [mM] | Reference |
Properties:
| 152.2200 [g/mol] | 1.34210 |
| 2 | 1 |
| 1 | 1 |
| 1 | |
| 3 [mg/kg B.W.] |
Identifiers:
| 103-85-5 |
| C7H8N2S |
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| FULZLIGZKMKICU-UHFFFAOYSA-N |
Links:
| [1] | 676454 | ||
| [2] | ZINC000003875720 | ||
| [3] | DB03694 |
