2-Heptyl-3-hydroxy-quinolone help

BitterDB id=957
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Freund J. R. et al. Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling, Journal of Biological Chemistry, 2018, 293, 25, 9824-9840 PubMed 29748385
[2] Lossow K, Hübner S, Roudnitzky N, Slack JP, Pollastro F, et al. (2016). Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans. J Biol Chem 291(29): 15358-77. PubMed 27226572

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r4 100.0 PubMed:29748385
Human  hTas2r14 PubMed:27226572
Human  hTas2r16 100.0 PubMed:29748385
Human  hTas2r38 100.0 PubMed:29748385
Mouse  mTas2r105 160 PubMed:27226572
Mouse  mTas2r121 100 PubMed:27226572

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

259.3500 [g/mol] 3.74660
2 2
2 2
6

Identifiers: help

108985-27-9,521313-35-9
C16H21NO2
CEIUIHOQDSVZJQ-UHFFFAOYSA-N

Links:

[1] 2763159