Diphenylthiourea, Sulfocarbanilide, sym-Diphenylthiourea, Thiocarbanilide help

BitterDB id=63 , Synthetic
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995
[2] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956
[5] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[6] Merck Index Monograph Number: 3333

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 PubMed:20022913
Human  hTas2r14 1700 PubMed:20022913
Human  hTas2r14 2.9 PubMed:17253962
Human  hTas2r38 0.3 PubMed:20022913
Fish  ccarpTas2r200-2 100.0 PubMed:34504956
Fish  ccarpTas2r203-1 100.0 PubMed:34504956

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

228.3200 [g/mol] 3.49550
2 1
2 2
2
49.9 [mg/kg B.W.]

Identifiers: help

102-08-9
C13H12N2S
FCSHMCFRCYZTRQ-UHFFFAOYSA-N

Links:

[1] 700999
[2] ZINC000003874019