3-oxo-C12-AHL, N-3-Oxo-Dodecanoyl-L-Homoserine Lactone help

BitterDB id=1784
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Maurer S. et al. Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone, Frontiers in Immunology, 2015, 6 PubMed 26257736
[2] Jaggupilli A. et al. Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs), ACS Infectious Diseases, 2018, 4(7), 1146–1156 PubMed 29799189

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r4 100.0 41.0 PubMed:29799189
Human  hTas2r14 50.0 70.0 PubMed:29799189
Human  hTas2r38 50.0 PubMed:26257736
Human  hTas2r49 200.0 58.0 PubMed:29799189

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

297.3899 [g/mol] 2.72860
1 4
0 1
12

Identifiers: help

C16H27NO4
PHSRRHGYXQCRPU-AWEZNQCLSA-N

Links:

[1] 3246941
[2] ZINC000008436851
[3] DB08324