BitterDB

hTAS2R49 - Taste receptor type 2 member 49

Alternative Names: Taste receptor type 2 member 20 TAS2R20 , Taste receptor type 2 member56 T2R56

Properties

Organism: Human
Location: chr12:11,148,561-11,150,474 UCSC
Number of known ligands: 3
MW: 35,358 (Da)
Sequence:

MMSFLHIVFSILVVVAFILGNFANGFIALINFIAWVKRQK ISSADQIIAALAVSRVGLLWVILLHWYSTVLNPTSSNLKV IIFISNAWAVTNHFSIWLATSLSIFYLLKIVNFSRLIFHH LKRKAKSVVLVIVLGSLFFLVCHLVMKHTYINVWTEECEG NVTWKIKLRNAMHLSNLTVAMLANLIPFTLTLISFLLLIY SLCKHLKKMQLHGKGSQDPSTKIHIKALQTVTSFLILLAI YFLCLIISFWNFKMRPKEIVLMLCQAFGIIYPSFHSFILI WGNKTLKQTFLSVLWQVTCWAKGQNQSTP

Known Ligands

Download SDF file of selected compounds.

	diphenidol
	cromolyn
	Methoxsalen,xanthotoxin

3D Homology Model

Click here to download the model PDB file.

When using this 3D model, please cite us:
Promiscuity and selectivity of bitter molecules and their receptors. Bioorg Med Chem 23 (2015) 4082-4091.
doi: 10.1016/j.bmc.2015.04.025

Protein Diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R49	EC1		K79E	0.2075	rs7135018
TAS2R49		4.58	V141I	0.1829	rs79420812
TAS2R49		4.6	H143Q	0.4231	rs12226920
TAS2R49	EC2		H148N	0.4283	rs12226919
TAS2R49		6.46	I236V	0.4229	rs10845281
TAS2R49	EC3		F252S	0.4229	rs10845280
TAS2R49	EC3		R255L	0.4231	rs10845279

Known Mutations Table

No mutations were reported yet.

Links and Citations:

UniProt	P59543
GPCRDB	t2r20_human
GeneCards	TAS2R20
The Human Protein Atlas	ENSG00000255837-TAS2R20

3D Visualizer: NGL: A WebGL Protein Viewer
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579. doi: 10.1093/nar/gkv402