hTAS2R4 - Taste receptor type 2 member 4
Properties
- Human
- chr7:141,478,289-141,479,188 UCSC
- 33
- 33,841 (Da)
-
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHR ISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYL SAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLL LKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELV TTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLI HSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYI PYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLI IITHPKLKTTAKKILCFKK
Known Ligands
Please scroll down to see the rest of the ligands.
Download SDF file of selected compounds.
3D Homology Model
Click here to download the model PDB file.
When using this 3D model, please cite us:
Promiscuity and selectivity of bitter molecules and their receptors. Bioorg Med Chem 23 (2015) 4082-4091.
doi: 10.1016/j.bmc.2015.04.025
Protein Diagram
When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper:
BitterDB paper
SNPs Table
| Receptor | Location | BW number | Residue | MAF | dbSNP |
| TAS2R4 | 1.33 | F7S | 0.4305 | rs2233998 | |
| TAS2R4 | 3.4 | V96L | 0.4734 | rs2234001 | |
| TAS2R4 | EC2 | S171N | 0.4914 | rs2234002 |
Known Mutations Table
| Receptor | Location | BW number | Residue | References |
| TAS2R4 | TM1 | 1.46 | G28 | doi: 10.1021/acs.jctc.5b00472 doi: 10.1111/j.1471-4159.2012.07808.x |
| TAS2R4 | TM3 | 3.26 | A90 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM3 | 3.27 | F91 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM3 | 3.28 | F92 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM4 | 4.61 | Y155 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | EC2 | 5.35 | N173 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | EC2 | 5.36 | T174 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM5 | 5.53 | I191 | doi: 10.1016/j.bbamem.2013.08.009 |
| TAS2R4 | IC3 | 6.24 | G216 | doi: 10.1016/j.bbamem.2013.08.009 |
| TAS2R4 | IC3 | 6.42 | Y234 | doi: 10.1016/j.bbamem.2013.08.009 |
| TAS2R4 | IC3 | 6.45 | I237 | doi: 10.1016/j.bbamem.2013.08.009 |
| TAS2R4 | TM6 | 6.59 | Y258 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM7 | 7.35 | K270 | doi: 10.3389/fmolb.2017.00063 |
| TAS2R4 | TM7 | 7.47 | P274 | doi: 10.1016/j.bbamem.2013.08.009 |
| TAS2R4 | TM7 | 7.47 | S285 | doi: 10.1021/acs.jctc.5b00472 doi: 10.1111/j.1471-4159.2012.07808.x |
Links and Citations:
3D Visualizer: NGL: A WebGL Protein Viewer
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579. doi: 10.1093/nar/gkv402