BitterDB

hTAS2R4 - Human (Homo sapiens) Taste Receptor Type 2 Member 4 help

Links and Citations:

Q9NYW5
ta2r4_human
TAS2R4
ENSG00000127364-TAS2R4
link

Properties help

  • Human
  • chr7:141,478,289-141,479,188 UCSC
  • 59
  • 33,841 (Da)


  • MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHR ISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYL SAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLL LKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELV TTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLI HSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYI PYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLI IITHPKLKTTAKKILCFKK

Known Ligands help

Experimental/ Computational 3D structures help

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

link

link

Protein Diagram help

Receptor snake diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table help

ReceptorLocationBW numberResidueMAFdbSNP
TAS2R41.33F7S0.4305rs2233998
TAS2R43.4V96L0.4734rs2234001
TAS2R4EC2 S171N0.4914rs2234002

Known Mutations Table help

ReceptorLocation BW number Residue References
hTAS2R4TM11.46G28doi: 10.1021/acs.jctc.5b00472 doi: 10.1111/j.1471-4159.2012.07808.x
hTAS2R4TM55.53I191doi: 10.1016/j.bbamem.2013.08.009
hTAS2R4IC36.24G216doi: 10.1016/j.bbamem.2013.08.009
hTAS2R4IC36.42Y234doi: 10.1016/j.bbamem.2013.08.009
hTAS2R4IC36.45I237doi: 10.1016/j.bbamem.2013.08.009
hTAS2R4TM77.47P274doi: 10.1016/j.bbamem.2013.08.009
hTAS2R4TM77.47S285doi: 10.1021/acs.jctc.5b00472 doi: 10.1111/j.1471-4159.2012.07808.x

Known SNP Table help

ReceptorLocation BW number Residue MAFdbSNP
hTAS2R40.00F62L0.0000rs2233999
hTAS2R41.33F7S0.4305rs2233998
hTAS2R40.00I191V0.0000rs2234003
hTAS2R40.00R3Q0.0000rs2233995
hTAS2R4EC2 0.00S171N0.4914rs2234002
hTAS2R40.00T74M0.0000rs2234000
hTAS2R43.40V96L0.4734rs2234001