BitterDB

hTAS2R43 - Taste receptor type 2 member 43

Alternative Names: Taste receptor type 2 member 52 T2R52

The closest relative of t2r43 is hT2R30 (44), which is 89% identical

Properties

Organism: Human
Location: chr12:11,243,886-11,244,912 UCSC
Number of known ligands: 19
MW: 35,519 (Da)
Sequence:

MITFLPIIFSSLVVVTFVIGNFANGFIALVNSIESFKRQK ISFADQILTALAVSRVGLLWVLLLNWYSTVLNPAFNSVEV RTTAYNIWAVINHFSNWLATTLSIFYLLKIANFSNFIFLH LKRRVKSVILVMLLGPLLFLACHLFVINMNEIVRTKEFEG NMTWKIKLKSAMYFSNMTVTMVANLVPFTLTLLSFMLLIC SLCKHLKKMQLRGKGSQDPSTKVHIKALQTVISFLLLCAI YFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILI WGNKKLKQTFLSVFWQMRYWVKGEKTSSP

Known Ligands

3D Homology Model

Click here to download the model PDB file.

When using this 3D model, please cite us:
Promiscuity and selectivity of bitter molecules and their receptors. Bioorg Med Chem 23 (2015) 4082-4091.
doi: 10.1016/j.bmc.2015.04.025

Protein Diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R43	IC1		W35S	0.3784	rs68157013
TAS2R43	IC3		H212R	0.3782	rs71443637

Known Mutations Table

Receptor	Location	BW number	Residue	References
TAS2R43	EC1	2.71	N76	doi: 10.3389/fmolb.2017.00063
TAS2R43	TM3	3.26	T82	doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064
TAS2R43	TM3	3.31	I87	doi: 10.3389/fmolb.2017.00063
TAS2R43	TM3	3.32	W88	doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.3389/fmolb.2017.00063
TAS2R43	TM3	3.33	A89	doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064
TAS2R43	TM3	3.35	I91	doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1093/chemse/bjh064 doi: 10.1371/journal.pone.0064675 doi: 10.3389/fmolb.2017.00063
TAS2R43	TM3	3.36	N92	doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064 doi: 10.1371/journal.pone.0064675 doi: 10.3389/fmolb.2017.00063
TAS2R43	TM7	7.39	K265	doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064
TAS2R43	TM7	7.42	R268	doi: 10.1021/acs.jctc.5b00472 doi: 10.1073/pnas.0913862107 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1093/chemse/bjh064

Links and Citations:

UniProt	P59537
GPCRDB	t2r43_human
GeneCards	TAS2R43
The Human Protein Atlas	ENSG00000255374-TAS2R43

3D Visualizer: NGL: A WebGL Protein Viewer
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579. doi: 10.1093/nar/gkv402

	Quinine
	Arborescin
	Arglabin
	Aristolochic acid
	Caffeine
	Falcarindiol
	diphenidol
	chloramphenicol
	amarogentin
	denatonium benzoate
	cromolyn
	Helicin
	acesulfame K
	aloin
	Grosheimin,grossheimin
	saccharin
	Epigallocatechin gallate,egcg
	denatonium saccharide
	pantothenic acid