hTAS2R43 - Taste receptor type 2 member 43
The closest relative of t2r43 is hT2R30 (44), which is 89% identical
Properties
- Human
- chr12:11,243,886-11,244,912 UCSC
- 19
- 35,519 (Da)
-
MITFLPIIFSSLVVVTFVIGNFANGFIALVNSIESFKRQK ISFADQILTALAVSRVGLLWVLLLNWYSTVLNPAFNSVEV RTTAYNIWAVINHFSNWLATTLSIFYLLKIANFSNFIFLH LKRRVKSVILVMLLGPLLFLACHLFVINMNEIVRTKEFEG NMTWKIKLKSAMYFSNMTVTMVANLVPFTLTLLSFMLLIC SLCKHLKKMQLRGKGSQDPSTKVHIKALQTVISFLLLCAI YFLSIMISVWSFGSLENKPVFMFCKAIRFSYPSIHPFILI WGNKKLKQTFLSVFWQMRYWVKGEKTSSP
Known Ligands 
Please scroll down to see the rest of the ligands.
Download SDF file of selected compounds.
3D Homology Model 
Click here to download the model PDB file.
When using this 3D model, please cite us:
Promiscuity and selectivity of bitter molecules and their receptors. Bioorg Med Chem 23 (2015) 4082-4091.
doi: 10.1016/j.bmc.2015.04.025
Protein Diagram 
When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper:
BitterDB paper
SNPs Table 
Receptor | Location | BW number | Residue | MAF | dbSNP |
TAS2R43 | IC1 | W35S | 0.3784 | rs68157013 | |
TAS2R43 | IC3 | H212R | 0.3782 | rs71443637 |
Known Mutations Table 
Links and Citations:
3D Visualizer: NGL: A WebGL Protein Viewer
AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579. doi: 10.1093/nar/gkv402