Genistein help

BitterDB id=800 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Roland WS, Vincken JP, Gouka RJ, van Buren L, Gruppen H, et al. (2011). Soy isoflavones and other isoflavonoids activate the human bitter taste receptors hTAS2R14 and hTAS2R39. J Agric Food Chem 59(21): 11764-71. PubMed 21942422
[2] URL link
[3] URL link
[4] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[5] Roland W. S. U. et al. Bitter Taste Receptor Activation by Flavonoids and Isoflavonoids: Modeled Structural Requirements for Activation of hTAS2R14 and hTAS2R39, J. Agric. Food Chem., 2013, 61, 44, 10454–10466 PubMed 24117141
[6] Li L. et al. A comprehensive review of the metabolism of citrus flavonoids and their binding to bitter taste receptors, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(3), 1763-1793 PubMed 36871162
[7] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[8] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 4.0 28.9 PubMed:21942422
Human  hTas2r14 4.0 28.9 PubMed:24117141
Human  hTas2r14 10.0 28.9 PubMed:27226572
Human  hTas2r14 4.0 28.9 PubMed:36871162
Human  hTas2r14 4.0 28.9 PubMed:37110532
Human  hTas2r39 8.0 49.4 PubMed:21942422
Human  hTas2r39 8.0 49.4 PubMed:24117141
Human  hTas2r39 8.0 49.4 PubMed:27226572
Human  hTas2r39 8.0 49.4 PubMed:36871162
Human  hTas2r39 8.0 49.4 PubMed:37110532
Mouse  mTas2r105 10 PubMed:27226572
Mouse  mTas2r125 10 PubMed:27226572

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.0015 [mM] Reference

Properties: help

270.2400 [g/mol] 2.57680
3 5
3 3
1

Identifiers: help

C15H10O5
TZBJGXHYKVUXJN-UHFFFAOYSA-N

Links:

[1] 5280961
[2] ZINC000018825330
[3] DB01645
[4] 2826