Coumarin help

BitterDB id=49 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] George A . Burdock (2005) Fenaroli's Handbook of Flavor Ingredients, Fifth Edition, CRC Press bitter undertone
[2] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[3] URL link
[4] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[5] Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666
[6] Ziegler F. and Behrens M. Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions in vitro, Proceedings of the Royal Society B: Biological Sciences, 2021, 288(1947) PubMed 33784867
[7] Itoigawa A. et al. Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals, Molecular Biology and Evolution, 2022, 39(6) PubMed 35652727
[8] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[9] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r10 300.0 PubMed:20022913
Human  hTas2r14 300.0 PubMed:20022913
Chicken  ggTas2r1 300 PubMed:25180257
Chicken  ggTas2r2 30 PubMed:25180257
Mouse  mTas2r105 300 PubMed:27226572
Vampire Bat  droTas2r4 1000.0 PubMed:33784867
Vampire Bat  droTas2r7 1000.0 PubMed:33784867
Cattle  btTas2r16 300.0 PubMed:35652727
Fish  dreTas2r4 300.0 PubMed:33355666
Turkey  mgTas2r4 PubMed:37860623

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

146.1400 [g/mol] 1.79300
0 2
2 2
0

Identifiers: help

103802-83-1,91-64-5,97549-54-7
C9H6O2
ZYGHJZDHTFUPRJ-UHFFFAOYSA-N

Links:

[1] 323
[2] ZINC000000074709
[3] DB04665