Humulon, Humulone help

BitterDB id=36
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Intelmann, D. et al. Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer. Chemosensory Perception 2, 118-132(2009). springerlink
[2] URL link
[3] URL link
[4] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[5] Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711
[6] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[7] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532
[8] Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835
[9] Merck Index Monograph Number: 4754
[10] PubChem 72625

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 0.1 1.4 PubMed:20022913
Human  hTas2r1 0.1 1.4 Link
Human  hTas2r1 0.1 1.4 PubMed:37110532
Human  hTas2r1 0.1 1.4 Link
Human  hTas2r14 0.01 PubMed:20022913
Human  hTas2r14 0.01 Link
Human  hTas2r40 0.01 0.4 PubMed:20022913
Human  hTas2r40 0.1 0.4 Link
Human  hTas2r40 30.0 PubMed:34785711
Human  hTas2r40 0.1 0.4 PubMed:37110532
Human  hTas2r40 0.01 0.4 Link
Human  hTas2r47 PubMed:37110532
Mouse  mTas2r105 1.0 PubMed:27226572

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.021 [mM] Reference
Bitter recognition threshold 0.021 [mM] Reference
Bitter recognition threshold 0.021 [mM] Reference

Properties: help

362.4700 [g/mol] 4.25220
3 5
0 1
7

Identifiers: help

26472-41-3
C21H30O5
VMSLCPKYRPDHLN-NRFANRHFSA-N

Links:

[1] 72625
[2] ZINC000100017288 ZINC000100071914