(-)-alpha Thujone help

BitterDB id=90 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] URL link
[3] URL link
[4] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[5] Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956
[6] Gibbs M. et al. Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion, PLOS ONE, 2022, 17(11) PubMed 36449493
[7] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[8] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r10 100.0 PubMed:20022913
Human  hTas2r10 100.0 PubMed:15178431
Human  hTas2r14 3.0 17.12 PubMed:20022913
Human  hTas2r14 3.0 17.12 PubMed:15178431
Chicken  ggTas2r7 300.0 PubMed:25180257
Mouse  mTas2r105 30.0 200.0 PubMed:27226572
Mouse  mTas2r119 30.0 80.0 PubMed:27226572
Dog  cfTas2r1 25.0 PubMed:36449493
Fish  ccarpTas2r200-1 300.0 PubMed:34504956
Turkey  mgTas2r3 PubMed:37860623

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

152.2400 [g/mol] 2.25760
0 1
0 2
1
499 [mg/kg B.W.]

Identifiers: help

546-80-5,59573-80-7
C10H16O
USMNOWBWPHYOEA-MRTMQBJTSA-N

Links: