Adlupulone help

BitterDB id=81 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Intelmann, D. et al. Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer. Chemosensory Perception 2, 118-132(2009). springerlink
[2] URL link
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875
[5] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 1 2.2 Link
Human  hTas2r1 1.0 2.2 Link
Human  hTas2r14 3.0 4.1 Link
Human  hTas2r14 1.0 2.2 PubMed:37110532
Human  hTas2r14 3.0 4.1 Link

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.037 [mM] Reference
Bitter recognition threshold 0.037 [mM] Reference
Bitter recognition threshold 0.037 [mM] Reference

Properties: help

414.5900 [g/mol] 6.86380
2 4
0 1
9

Identifiers: help

C26H38O4
QXPOWGXRDUFAQW-UHFFFAOYSA-N

Links:

[1] 9909740
[2] ZINC000009133221