Trans-Isohumulone help

BitterDB id=79 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Intelmann, D. et al. Three TAS2R Bitter Taste Receptors Mediate the Psychophysical Responses to Bitter Compounds of Hops (Humulus lupulus L.) and Beer. Chemosensory Perception 2, 118-132(2009). springerlink
[2] URL link
[3] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[4] Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 0.3 9 Link
Human  hTas2r1 0.3 9.0 PubMed:37110532
Human  hTas2r1 0.3 9.0 Link
Human  hTas2r14 1.0 11.2 Link
Human  hTas2r14 1.0 11.2 Link

Sensory data about the compound bitterness: help

Sensory Data Type Value Reference
Bitter recognition threshold 0.02 [mM] Reference
Bitter recognition EC50 0.2 [mM] Reference
Bitter recognition threshold 0.02 [mM] Reference

Properties: help

362.4700 [g/mol] 3.62540
2 5
0 1
8

Identifiers: help

C21H30O5
QARXXMMQVDCYGZ-QVKFZJNVSA-N

Links:

[1] 11175902
[2] ZINC000005114391