BitterDB ID=1341

Quinine sulfate, Quinine sulphate

BitterDB id=1341
Detailed experimental validation described in the associated resource.

References for the compound bitterness

	Resource	Comment
[1]	Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666
[2]	Ziegler F. and Behrens M. Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions in vitro, Proceedings of the Royal Society B: Biological Sciences, 2021, 288(1947) PubMed 33784867
[3]	Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[4]	Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623

Known bitter receptors targets:

Receptor Name	Effective concentration (μM)	EC50 (μM)	References
ggTas2r1			PubMed:37860623
ggTas2r2			PubMed:37860623
ggTas2r7			PubMed:37860623
droTas2r7	30.0		PubMed:33784867
dreTas2r3a	10.0		PubMed:33355666
mgTas2r3			PubMed:37860623
mgTas2r4			PubMed:37860623

Sensory data about the compound bitterness:

There is no sensory data available

Properties:

Mol. Weight: 746.9120 [g/mol]	AlogP(octanol-water): 4.80980
# Hydrogen Bond Donor: 2	# Hydrogen Bond Acceptor: 8
# Aromatic Rings: 4	# Rings: 8
# Rotatable Bonds: 8

Identifiers:

Formula: C40H50N4O8S

IUPAC Systematic Name:

SMILES:

Canonical SMILES:

InChI Key: RONWGALEIBILOG-VMJVVOMYSA-N

Links:

[1]

PubChem