Flufenamic Acid help

BitterDB id=65 , Synthetic
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[3] Di Pizio A. et al. Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back, Cell. Mol. Life Sci., 2020, 77, 531–542 PubMed 31236627
[4] Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711
[5] Huang T.-T. et al. Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2, Food & Function, 2022, 13, 242-254 PubMed 34881772
[6] Itoigawa A. et al. Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals, Molecular Biology and Evolution, 2022, 39(6) PubMed 35652727
[7] Waterloo L. et al. Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14, Journal of Medicinal Chemistry, 2023, 66, 5, 3499–3521 PubMed 36847646
[8] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[9] Fierro F. et al. Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands, Cellular and Molecular Life Sciences, 2023, 80, 114 PubMed 37012410
[10] Chen S. et al. Anti-HIV drugs lopinavir/ritonavir activate bitter taste receptors, Chemical Senses, 2023, 48 PubMed 37625013

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 0.01 PubMed:20022913
Human  hTas2r14 300.0 PubMed:34785711
Human  hTas2r14 0.3 PubMed:37012410
Human  hTas2r14 20.0 PubMed:34881772
Human  hTas2r14 300.0 PubMed:37625013
Human  hTas2r14 0.43 PubMed:36847646
Human  hTas2r14 0.2378 PubMed:31236627
Echidna  tacTas2r814 30.0 PubMed:35652727

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

281.2300 [g/mol] 4.14720
2 2
2 2
3
249 [mg/kg B.W.]

Identifiers: help

530-78-9
C14H10F3NO2
LPEPZBJOKDYZAD-UHFFFAOYSA-N

Links:

[1] 3371
[2] ZINC000000086535
[3] DB02266
[4] 2447