Erythromycin help

BitterDB id=99 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995
[2] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[3] URL link
[4] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[5] Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835
[6] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[7] Behrens M. et al. A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception, Proceedings of the National Academy of Sciences, 2023, 120(48) PubMed 37956436

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 PubMed:37413835
Human  hTas2r10 300.0 PubMed:20022913
Chicken  ggTas2r7 300.0 PubMed:25180257
Mouse  mTas2r123 300.0 PubMed:27226572
Shark  scTas2r1 300.0 PubMed:37956436
Shark  cplTas2r1 300.0 PubMed:37956436
Bird  tgTas2r1 900.0 PubMed:37860623
Turkey  mgTas2r3 PubMed:37860623

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

733.9400 [g/mol] 1.78560
5 14
0 3
7
4600 [mg/kg B.W.]

Identifiers: help

114-07-8,7704-67-8,79235-06-6,82343-12-2
C37H67NO13
ULGZDMOVFRHVEP-RWJQBGPGSA-N

Links:

[1] 12560
[2] DB00199
[3] 1456