BitterDB id=645 Detailed experimental validation described in the associated resource.
References for the compound bitterness
Resource
Comment
[1]
Sakurai T, Misaka T, Ishiguro M, Masuda K, Sugawara T, et al. (2010). Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16. J Biol Chem 285(36): 28373-8. PubMed 20605788
[2]
Imai H. et al. Functional diversity of bitter taste receptor TAS2R16 in primates, Biology Letters, 2012, 8(4) PubMed 22399783
[3]
Thomas A. et al. The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket, Scientific Reports, 2017, 7, 7753 PubMed 28798468
[4]
Itoigawa A. et al. A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation, 2019, 286, 1904 PubMed 31161904
[5]
Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[6]
Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532
[7]
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 32(3): 397-401. PubMed 12379855
hTas2r16
mTas2r119
ptTas2r16