Chloroquine  phosphate help

BitterDB id=641
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302
[2] Wang Y. et al. Functional divergence of bitter taste receptors in a nectar-feeding bird, Biology Letters, 2019, 15(9) PubMed 31551065
[3] Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[4] Behrens M. et al. A singular shark bitter taste receptor provides insights into the evolution of bitter taste perception, Proceedings of the National Academy of Sciences, 2023, 120(48) PubMed 37956436
[5] Itoigawa A. et al. Evolutionary origins of bitter taste receptors in jawed vertebrates, Current Biology, 2024, 34(7), 271-272 PubMed 38593768
[6] Merck Index Monograph Number: 2163

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r2 3000.0 PubMed:36929150
Cat  fcTas2r7 10000.0 PubMed:26488302
Fish  ppeTas2r1 10000.0 PubMed:38593768
Shark  scTas2r1 10000.0 PubMed:37956436
Shark  cpuTas2r1 10000.0 PubMed:38593768
Shark  stTas2r1 10000.0 PubMed:38593768
Stingray  hakTas2r1 10000.0 PubMed:38593768
Bird  ccaroTas2r1 10000.0 PubMed:31551065

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

515.8700 [g/mol] 2.95340
7 5
2 2
8

Identifiers: help

50-63-5
C18H32ClN3O8P2
QKICWELGRMTQCR-UHFFFAOYSA-N

Links:

[1] 64927
[2] ZINC000019144226 ZINC000019144231
[3] 5535