BitterDB ID=1766

Chlorpheniramine maleate, Chlorpheniramine maleate salt

BitterDB id=1766
Detailed experimental validation described in the associated resource.

References for the compound bitterness

	Resource	Comment
[1]	Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302
[2]	Wang Y. et al. Functional divergence of bitter taste receptors in a nectar-feeding bird, Biology Letters, 2019, 15(9) PubMed 31551065
[3]	Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150
[4]	URL link

Known bitter receptors targets:

Receptor Name	Effective concentration (μM)	EC50 (μM)	References
fcTas2r2	100.0		PubMed:26488302
fcTas2r46	100.0		PubMed:26488302
cannTas2r1a	100.0		PubMed:31551065
ccaroTas2r1	100.0		PubMed:31551065

Sensory data about the compound bitterness:

Sensory Data Type	Value	Reference
Bitter recognition threshold	0.085 [mM]	Reference

Properties:

Mol. Weight: 390.8606 [g/mol]	AlogP(octanol-water): 3.47140
# Hydrogen Bond Donor: 0	# Hydrogen Bond Acceptor: 1
# Aromatic Rings: 2	# Rings: 2
# Rotatable Bonds: 7

Identifiers:

Formula: C20H23ClN2O4

IUPAC Systematic Name:

SMILES:

Canonical SMILES:

InChI Key: DBAKFASWICGISY-BTJKTKAUSA-N

Links:

[1]

PubChem