Denatonium help

BitterDB id=1620
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Sandau M. M. et al. A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs, BMC Neuroscience, 2015, 16(33) PubMed 26037485
[2] Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711
[3] Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r1 PubMed:37413835
Human  hTas2r41 PubMed:37413835
Human  hTas2r43 1000.0 1206.0 PubMed:26037485
Human  hTas2r47 300.0 PubMed:34785711
Cat  fcTas2r43 1000.0 217.0 PubMed:26037485
Dog  cfTas2r43 217.0 PubMed:26037485

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

325.4678 [g/mol] 2.85520
1 1
2 2
8

Identifiers: help

C21H29N2O+
ZFQMTVNLDNXRNQ-UHFFFAOYSA-O

Links:

[1] 15488
[2] ZINC000001601437