BitterDB

hTAS2R45 - Human (Homo sapiens) Taste Receptor Type 2 Member 45

Alternative Names: G-protein coupled receptor 59 GPR59

Links and Citations:

UniProt	P59539
GPCRDB	t2r45_human
GeneCards	TAS2R45
IUPHAR/BPS	link

Properties

Organism: Human
Location: chr12:1653159-1652260
Number of known ligands:
MW: 34,278 (Da)
Sequence:

MITFLPIIFSILVVVTFVIGNFANGFIALVNSTEWVKRQK ISFADQIVTALAVSRVGLLWVLLLNWYSTVLNPAFCSVEL RTTAYNIWAVTGHFSNWPATSLSIFYLLKIANFSNLIFLR LKRRVKSVILVVLLGPLLFLACHLFVVNMNQIVWTKEYEG NMTWKIKLRRAMYLSDTTVTMLANLVPFTVTLISFLLLVC SLCKHLKKMQLHGKGSQDPSTKVHIKVLQTVISFFLLRAI YFVSVIISVWSFKNLENKPVFMFCQAIGFSCSSAHPFILI WGNKKLKQTYLSVLWQMRY

Known Ligands

No ligand has been identified.

Experimental/ Computational 3D structures

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

RCSB PDB: link

AlphaFold: link

Protein Diagram

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

SNPs Table

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R45		4.49	V132M		rs11526470
TAS2R45		6.48	C238R		rs3759245

Known Mutations Table

No mutations were reported yet.

Known SNP Table

Receptor	Location	BW number	Residue	MAF	dbSNP
hTAS2R45		6.48	C238R	0.0000	rs3759245
hTAS2R45		4.49	V132M	0.0000	rs11526470