BitterDB ID=937

Mefenamic acid help

BitterDB id=937
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Ayenew Z, Puri V, Kumar L, Bansal AK (2009). Trends in pharmaceutical taste masking technologies: a patent review. Recent Pat Drug Deliv Formul 3(1): 26-39. PubMed 19149727
[2] Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, et al. (2014). The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14. FASEB J 28(3): 1181-97. PubMed 24285091
[3] Alshehri SM, Park JB, Alsulays BB, Tiwari RV, Almutairy B, et al. (2015). Mefenamic acid taste-masked oral disintegrating tablets with enhanced solubility via molecular interaction produced by hot melt extrusion technology. J Drug Deliv Sci Technol 27: 18-27. PubMed 25914727 intensely bitter taste

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r14 3 PubMed:24285091

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

241.29 [g/mol] 3.74524
2 2
2 2
3
740 [mg/kg B.W.]

Identifiers: help

61-68-7
C15H15NO2
HYYBABOKPJLUIN-UHFFFAOYSA-N

Links:

[1] 4044
[2] ZINC000000020241
[3] DB00784
[4] 2593