BitterDB ID=315

Methoxsalen, xanthotoxin help

BitterDB id=315 , Natural
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Mancuso G, Borgonovo G, Scaglioni L, Bassoli A (2015). Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules 20(10): 18907-22. PubMed 26501253
[2] Merck Index Monograph Number: bitter taste followed by tingling sensation

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r10 100 PubMed:27226572
Human  hTas2r10 20600 PubMed:26501253
Human  hTas2r14 100 PubMed:27226572
Human  hTas2r14 10800 PubMed:26501253
Human  hTas2r46 100 PubMed:27226572
Human  hTas2r49 12000 PubMed:26501253
Mouse  mTas2r105 10 PubMed:27226572
Mouse  mTas2r119 100 PubMed:27226572
Mouse  mTas2r120 30 PubMed:27226572
Mouse  mTas2r121 100 PubMed:27226572
Mouse  mTas2r135 100 PubMed:27226572

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

216.19 [g/mol] 2.54780
0 4
3 3
1
790 [mg/kg B.W.]

Identifiers: help

298-81-7,56-93-9
C12H8O4
QXKHYNVANLEOEG-UHFFFAOYSA-N

Links:

[1] 4114
[2] ZINC000002548959
[3] DB00553