Strychnine 
BitterDB id=100 , Natural
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [2] | URL link | |
| [3] | Liu K. et al. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018, 1860, 5, 991-999 PubMed 29355483 | |
| [4] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [5] | Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956 | |
| [6] | Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711 | |
| [7] | Itoigawa A. et al. Functional Diversity and Evolution of Bitter Taste Receptors in Egg-Laying Mammals, Molecular Biology and Evolution, 2022, 39(6) PubMed 35652727 | |
| [8] | Yan J. and Tong H. An overview of bitter compounds in foodstuffs: Classifications, evaluation methods for sensory contribution, separation and identification techniques, and mechanism of bitter taste transduction, Comprehensive Reviews in Food Science and Food Safety, 2023, 22(1), PubMed 36382875 | |
| [9] | Yang J. et al. Discovery and verification of bitter components in Panax notoginseng based on the integrated strategy of pharmacophore model, system separation and bitter tracing technology, Food Chemistry, 2023, 428, 136716 PubMed 37413835 | |
| [10] | URL link | intense bitter taste |
| [11] | Merck Index Monograph Number: 8855 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References | Sequence variant |
|---|---|---|---|---|
hTas2r1 |
PubMed:37413835 | |||
|
hTas2r7 |
100.0 | PubMed:20022913 | ||
|
hTas2r10 |
3.0 | 29.3 | PubMed:20022913 | |
|
hTas2r10 |
21.8 | PubMed:24266887 | ||
|
hTas2r46 |
0.1 | 0.45 | PubMed:20022913 | AAM19318.1 |
|
hTas2r46 |
0.43 | PubMed:17595105 | ||
|
hTas2r46 |
300.0 | PubMed:34785711 | ||
mTas2r117 |
10.0 | PubMed:27226572 | ||
|
mTas2r140 |
10.0 | PubMed:27226572 | ||
oaTas2r811 |
30.0 | PubMed:35652727 | ||
|
oaTas2r812 |
30.0 | PubMed:35652727 | ||
dreTas2r3a |
30.0 | PubMed:33355666 | ||
|
ccarpTas2r200-1 |
30.0 | PubMed:34504956 | ||
|
ccarpTas2r202-1 |
30.0 | PubMed:34504956 |
Sensory data about the compound bitterness:
| Sensory Data Type | Value | Reference |
|---|---|---|
| Bitter recognition threshold | 0.003 [mM] | Reference |
| Bitter recognition threshold | 0.0016 [mM] | Reference |
Properties:
| 334.4200 [g/mol] | 2.09250 |
| 0 | 3 |
| 1 | 7 |
| 0 | |
| 2.35 [mg/kg B.W.] |
Identifiers:
| 57-24-9 |
| C21H22N2O2 |
|
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|
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| QMGVPVSNSZLJIA-FVWCLLPLSA-N |
Links:
| [1] | 441071 | ||
| [2] | ZINC000000119434 | ||
| [3] | 347 |
