Picrotin 
BitterDB id=931
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Behrens M, Brockhoff A, Kuhn C, Bufe B, Winnig M, et al. (2004). The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem Biophys Res Commun 319(2): 479-85. PubMed 15178431 | |
| [2] | URL link | |
| [3] | URL link | |
| [4] | Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422 | |
| [5] | Ziegler F. and Behrens M. Bitter taste receptors of the common vampire bat are functional and show conserved responses to metal ions in vitro, Proceedings of the Royal Society B: Biological Sciences, 2021, 288(1947) PubMed 33784867 | |
| [6] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [7] | URL link | highly bitter |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r10 |
1000.0 | PubMed:15178431 | |
|
hTas2r10 |
1000.0 | PubMed:27226572 | |
|
hTas2r14 |
30.0 | PubMed:15178431 | |
|
hTas2r14 |
1000.0 | PubMed:27226572 | |
|
hTas2r46 |
30 | PubMed:17595105 | |
|
hTas2r46 |
1000.0 | PubMed:15178431 | |
|
hTas2r46 |
1000.0 | PubMed:27226572 | |
mTas2r105 |
3000.0 | PubMed:27226572 | |
|
mTas2r114 |
1000.0 | PubMed:27226572 | |
|
mTas2r120 |
1000.0 | PubMed:27226572 | |
|
mTas2r121 |
1000.0 | PubMed:27226572 | |
|
mTas2r135 |
1000.0 | PubMed:27226572 | |
droTas2r7 |
1000.0 | PubMed:33784867 |
Sensory data about the compound bitterness:
| There is no sensory data available |
Properties:
| 310.3000 [g/mol] | -0.86720 |
| 2 | 7 |
| 0 | 5 |
| 1 |
Identifiers:
| C15H18O7 |
|
|
|
|
| RYEFFICCPKWYML-QCGISDTRSA-N |
Links:
| [1] | 442291 | ||
| [2] | ZINC000003995861 |
